"Ion channels are a cells gateways for ions to pass in and out thus changing the environment both inside and out. They are pivotal to physiology and homeostasis. Ion channel research has given us modern day medicines and continues to provide novel insights into alleviating the most complex of human diseases."
The groups of Mark Dallas, Francesco Tamagnini and Gary Stephens comprise the Reading Ion Channels Group who collectively use in vitro and in vivo electrophysiology to pursue research interests encompassing ion channel and receptor targets in neurodegeneration, epilepsy, bipolar disorder and pain states. We have access to both manual and automated patch clamp platforms as well as multielectrode array and multiphoton capabilities to explore bioelectricity in many different formats and experimental set ups. The research labs are located in the Hopkins Building on the Whiteknights campus of the University of Reading. Find us here.
Ion Channels as Targets in Drug Discovery
This book provides a cutting-edge translational reference on current ion channel drug discovery and how academia and industry are exploiting knowledge of ion channel structure and function to correct the pathophysiology associated with debilitating conditions, including cystic fibrosis, pain, epilepsy, and neurodegenerative disorders.
Latest Publications
- Anti-AMPA Receptor Autoantibodies Reduce Excitatory Currents in Rat Hippocampal Neurons
- Kv1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication
- Identification of tauopathy-associated lipid signatures in 2 Alzheimer’s disease mouse brain using label-free 3 chemical imaging
- Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates the gabapentin-mediated analgesia
- Tau-mediated synaptic dysfunction is coupled with HCN channelopathy
Funding Success
- Voltage-Gated Calcium Channels in Bipolar Disorder
- Immune cell K+ dysfunction in response to pollution
- Mechanisms of neuronal dysfunction associated with pathogenic truncated tau
- Lipid invasion model. A new theory to explain the pathogenesis of Alzheimer's disease
- Nanoplastics in the food chain: from food, to cells, to function
- Botulinum neurotoxins for the treatment of chronic pain
Credits:
Mark Dallas, Gary Stephens