The Ziolkowski lab LABORATORY of genome biology, adam mickiewicz university

We're organising the PLANT MEIOSIS MEETING next year!!!

Come to Poznan, Poland, to meet with our community!

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The variation observed between parents and their offspring is due to meiotic recombination called crossover. The crossover takes place during gamete formation and is based on exchange of chromosomal segments between parental chromosomes. In consequence, novel combinations of alleles are generated. We are interested in how crossovers are formed and how they are regulated.

Different factors that control meiotic recombination: acting in cis and trans Modified from Ziolkowski and Henderson, New Phytologist 2017.

Our primary research model is Arabidopsis thaliana - favoured species of plant scientists. However, we work also on maize and barley.

Read more about our research in here.

Selected papers

Dluzewska J, Dziegielewski W, Szymanska-Lejman M, Gazecka M, Henderson IR, Higgins JD, Ziolkowski PA. (2023) MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism. Nat Commun 14: 6716.

Szymanska-Lejman M, Dziegielewski W, Dluzewska J, Kbiri N, Bieluszewska A, Poethig RS, Ziolkowski PA. (2023) The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids. Nat Commun 14: 33.

Bieluszewski T*, Sura W*, Dziegielewski W*, Bieluszewska A, Lachance C, Kabza M, Szymanska-Lejman M, Abram M, Wlodzimierz P, De Winne N, De Jaeger G, Sadowski J, Côté J & Ziolkowski PA (2022) NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis. Nat Commun 13: 277.

Zhu L, Fernández-Jiménez N, Szymanska-Lejman M, Pelé A, Underwood CJ, Serra H, Lambing C, Dluzewska J, Bieluszewski T, Pradillo M, Henderson IR, Ziolkowski PA (2021) Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in ArabidopsisProc Natl Acad Sci U S A 118: e2021970118.

Blackwell AR, Dluzewska J, Szymanska-Lejman M, Desjardins S, Tock AJ, Kbiri N, Lambing C, Lawrence EJ, Bieluszewski T, Rowan B, Higgins JD, Ziolkowski PA, Henderson IR (2020) MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis. EMBO J 39: e104858.

Sura W, Kabza M, Karlowski WM, Bieluszewski T, Kus-Slowinska M, Pawełoszek Ł, Sadowski J, Ziolkowski PA (2017) Dual role of the histone variant H2A.Z in transcriptional regulation of stress-response genes. Plant Cell 29: 791-807.

Ziolkowski PA, Underwood CJ, Lambing C, Martinez-Garcia M, Lawrence EJ, Ziolkowska L, Griffin C, Choi K, Franklin FC, Martienssen RA, Henderson IR. (2017) Natural variation and dosage of the HEI10 meiotic E3 ligase control Arabidopsis crossover recombination. Genes Dev 31: 306-317.

Adam Mickiewicz University - Collegium Minus

The Institute is a part of Adam Mickiewicz University in Poznan

Faculty of Biology UAM - Collegium Biologicum

We are located in the Institute of Molecular Biology and Biotechnology in Collegium Biologicum, a new development for biologists

Our funding:

Contact us: tel. +48 61 829 5966

Laboratory of Genome Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznan, Poland