Laboratory of Mucosal Biology

Since 2022

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Mission

To uncover how mucosal barriers integrate intrinsic and extrinsic signals within the gut-liver axis in health and disease

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Team members

Dr. Alexandre Denadai-Souza, Assistant Professor

Dr. Cansu Akkaya, Senior Research Associate

MSc. Matthias van Sligtenhorst, PhD Student

MSc. Femke van Geest, PhD Student

MSc. Shi Gao, PhD Student

Ms. Giethe Soons, Bachelor Student

Dr. Janaíne Prata, Alumna

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Our expertise

Single-Cell Omics

High-throughput single-cell transcriptome and proteomic profiling of human intestinal epithelial and immune cells

Technologies

GEM-X 3' Gene Expression

GEM-X 5' Immune Profiling and BCR/TCR clonotyping

High Dimensional Spectral Flow Cytometry

Disease modelling with organoids

Technologies

Proprietary chemically defined media

Small and large human intestinal organoids

Transgenic organoids and biosensors

Host-microbiota interaction

Technologies

Anaerobic, microaerophilic and hypoxic cell (co-) culture

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Latest contributions

Epithelial dysfunction as a driver of symptoms in GI disorders
A Roadmap for the Human Gut Cell Atlas
RNA Rescue Spatial Transcriptomics

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Resources

coming soon...

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Academic and scientific affiliation

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Industry partners

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Institutional address and contact information