Laboratory of Mucosal Biology

Since 2022

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Mission

To uncover how mucosal barriers integrate intrinsic and extrinsic signals within the gut-liver axis in health and disease

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Team members

Dr. Alexandre Denadai-Souza, Assistant Professor

Dr. Cansu Akkaya, Senior Research Associate

MSc. Matthias van Sligtenhorst, PhD Student

MSc. Femke van Geest, PhD Student

MSc. Shi Gao, PhD Student

Dr. Janaíne Prata, Alumna

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Our expertise

Single-Cell Omics

High-throughput single-cell transcriptome and proteomic profiling of human intestinal epithelial and immune cells

Technologies

GEM-X 3' Gene Expression

GEM-X 5' Immune Profiling and BCR/TCR clonotyping

High Dimensional Spectral Flow Cytometry

Disease modelling with organoids

Technologies

Proprietary chemically defined media

Small and large human intestinal organoids

Transgenic organoids and biosensors

Host-microbiota interaction

Technologies

Anaerobic, microaerophilic and hypoxic cell (co-) culture

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Latest contributions

Epithelial dysfunction as a driver of symptoms in GI disorders
A Roadmap for the Human Gut Cell Atlas
RNA Rescue Spatial Transcriptomics

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Resources

coming soon...

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Academic and scientific affiliation

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Industry partners

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Institutional address and contact information