About Us
Located on the ASU Downtown Phoenix campus, our lab resides in the ISTB-8 building. Here in the JKS lab, we take molecular-level approaches to achieve our goals of increasing the health span and delaying retinal degeneration. We use a combination of computational, experimental, analytical, structural, multi-omics-based, and cellular data analysis-based approaches. We study both, model and non-model organisms, including humans, corals, sharks, and others. Our wide array of research areas is united by our overall goals of finding practical, actionable measures to assist with healthy aging and treatment for those dealing with certain rare diseases.
Projects
Healthy Aging
Goal: Extend healthspan.
Our aim is to improve our fundamental understanding of the aging process with the translational goal of possibly turning back the clock on aging through biomarker feedback informed interventions. We strive to improve metabolic health, which is known to diminish with age. Our research is focused on healthy aging in model and non-model organisms, including humans, corals, and sharks.
Retinitis Pigmentosa & Other Rare Diseases
Goal: Delay retinal degeneration.
Our work on retinitis pigmentosa, which causes retinal degeneration, involves offsetting the effects of mutations in the proteins Rhodopsin and Usherin through multi-omics data integration generated hypotheses.
Targetome
Goal: Identify multiple protein targets.
Our work on the targetome, a collection of human proteins with at least one experimentally derived 3D structure, is based on the idea that molecules have multiple predicted binding targets.
People
- Dr. Judith Klein-Seetharaman (Principal Investigator; pictured left)
- Dr. Latha Kannan (Laboratory Manager)
- Dr. Chase Harms (Postdoctoral Researcher)
- Meghana Murthy (PhD Candidate)
- Naven Goh (PhD Student)
- Shazeen Imtiaz (PhD Student)
- Kristina Wechsler (PhD Student)
Make a Lasting Impact.
Volunteer in the JKS Lab
Dedicate your valuable time to the JKS lab to contribute towards the one-of-a-kind research projects our lab is currently involved. Contact Dr. Klein at jkleinse@asu.edu to discuss your options.
Donate to Valuable Research Projects
Donate to the JKS lab today to contribute towards crucial research that fights blindness and aims to increase the health span of living organisms! Please click the links below to be redirected to the ASU Foundation for a New American University website where you can donate to either of our two ongoing projects.
Technical issues when accessing the donation pages? You can also search for the project names ("Research to Fight Blindness" and "Increase Healthspan") in the ASU Foundation website:
Citations
[1] Murthy, M. H. S., Jasbi, P., Lowe, W., Kumar, L., Olaosebikan, M., Roger, L., Yang, J., Lewinski, N., Daniels, N., Cowen, L., & Klein-Seetharaman, J. (2024). Insulin signaling and pharmacology in humans and in corals. PeerJ, 12, e16804. https://doi.org/10.7717/peerj.16804
[2] Rozewski, E., Taqi, O., Fini, E. H., Lewinski, N. A., & Klein-Seetharaman, J. (2023). Systems biology of asphalt pollutants and their human molecular targets. Frontiers in Systems Biology, 2, 928962. https://doi.org/10.3389/fsysb.2022.928962
Get in touch at jkleinse@asu.edu